Allergens in Urban Schools and Homes of Children with Asthma

Perdita Permaul, Elaine Hoffman, Chunxia Fu, William Sheehan, Sachin Baxi, Jonathan Gaffin, Jeffrey Lane, Ann Bailey, Eva King, Martin Chapman, Diane Gold, Wanda Phipatanakul

Abstract

 

Background

 

Most studies of indoor allergens have focused on the home environment. However, schools may be an important site of allergen exposure for children with asthma. We compared school allergen exposure to home exposure in a cohort of children with asthma. Correlations between settled dust and airborne allergen levels in classrooms were examined.

 

Methods

 

Settled dust and airborne samples from 12 inner-city schools were analyzed for indoor allergens using multiplex array technology (MARIA). School samples were linked to students with asthma enrolled in the School Inner-City Asthma Study (SICAS). Settled dust samples from students’ bedrooms were analyzed similarly.

 

Results

 

From schools, 229 settled dust and 197 airborne samples were obtained. From homes, 118 settled dust samples were obtained. Linear mixed regression models of log-transformed variables showed significantly higher settled dust levels of mouse, cat and dog allergens in schools than homes (545% higher for Mus m 1, estimated absolute difference 0.55 gg/g, p < 0.0001; 198% higher for Fel d 1, estimated absolute difference 0.13 gg/g, p = 0.0033; and 144% higher for Can f 1, estimated absolute difference 0.05 gg/g, p = 0.0008). Airborne and settled dust Mus m 1 levels in classrooms were moderately correlated (r = 0.48; p < 0.0001). There were undetectable to very low levels of cockroach and dust mite allergens in both homes and schools.

 

Conclusion

 

Mouse allergen levels in schools were substantial. In general, cat and dog allergen levels were low, but detectable, and were higher in schools. Aerosolization of mouse allergen in classrooms may be a significant exposure for students. Further studies are needed to evaluate the effect of indoor allergen exposure in schools on asthma morbidity in students with asthma.

 

Authors


Perdita Permaul - 1,2

Elaine Hoffman - 3

Chunxia Fu - 4

William Sheehan - 2,5

Sachin Baxi - 2,5

Jonathan Gaffin - 2,s

Jeffrey Lane - 7

Ann Bailey - 4

Eva King - 8

Martin Chapman - 8

Diane Gold - 2,4

Wanda Phipatanakul - 2,4,5

 

1 - Division of Pediatric Pulmonary, Allergy and Immunology, Department of Pediatrics, Massachusetts General Hospital, Boston, MA, USA;

2 - Harvard Medical School, Boston, MA, USA;

3 - Department of Biostatistics, Harvard School of Public Health, Boston, MA, USA;

4 - Division of Respiratory Epidemiology, Channing Laboratory, Brigham and Women’s Hospital, Boston, MA, USA;

5 - Division of Immunology, Department of Medicine, Children’s Hospital, Boston, MA, USA;

6 - Division of Pulmonary and Respiratory Diseases, Department of Medicine, Children’s Hospital, Boston, MA, USA;

7 - School Facilities Management, Boston, MA, USA; 8Indoor Biotechnologies Inc, Charlottesville, VA, USA

 

Pediatr Allergy Immunol2012: 00

 

ORIGINAL ARTICLE

 

Allergens in Urban Schools and Homes of Children with Asthma:  Created on March 25th, 2014.  Last Modified on April 14th, 2014

0 Comments

You must be logged in to comment:

Forgot your password?   Don't have an account?

CIRIscience.org Account Registration

Fill in the form below for basic site access (commenting, etc).
Looking for more? Become a CIRI Member...