CIRI Research

This site donated by:

Kaivac Cleaning Systems®

Support CIRI!

 

We Support CIRI - Cleaning Industry Research Institute

 

Show your support of CIRI with the 'CIRI Supporter' logo, available for display on your Web site upon joining CIRI.

 

Join today and help CIRI advance the cause of cleaner, more productive, and healther indoor environments through scientific research!

Popular Topics

Did You Know?

 

Shigella

 

There are more than 30 types of Shigella.

 

USDA

Article

Facts about Fungal Fragments

 

By CDC

 

Editor's Note: Mold spores are not the only concern, scientists say. Tinier pieces of mold called "fungal fragments" may be deeply inhaled and cause problems. The content below is from the CDC:

 

Exposure to fungi, particularly in water damaged indoor environments has been thought to exacerbate a number of adverse health effects including subjective symptoms such as fatigue, cognitive difficulties and problems with memory, to more definable diseases such as allergy, asthma and hypersensitivity pneumonitis. Understanding the role of fungal exposure in these environments has been limited by methodological difficulties in enumerating and identifying fungi in environmental air samples. Consequently, data on personal exposure and sensitization to fungal allergens has been restricted to the spores of a few select and easily identifiable species.

 

Fungal fragments

  • Derived from fragmented conidia or hyphae
  • Fungal fragments are categorized into two groups depending on the analysis used:

1. Submicron fungal fragments <1 micron

2. Larger fungal fragments >1 micron

  • Identification in environmental samples is complex and subjective.

The contribution of airborne spores, hyphae and fungal fragments of other genera to exposure and allergic sensitization are poorly characterized. There is increased interest in the role of aerosolized fungal fragments following reports that the combination of hyphal fragments and spore counts improved the association with asthma severity. Such fragments are categorized as either sub-micronic (less than one micron) particles or larger fungal fragments. In vitro studies have shown that sub-micronic particles of several fungal species are aerosolized in much higher concentrations (300-500 times) compared to spores, and that respiratory deposition models suggest that particles of Stachybotrys chartarum may be deposited 230-250 fold higher than spores.

 

The practical implications of these models are yet to be determined for actual human exposures ... These findings highlight the contribution of larger fungal fragments as aeroallergen sources and present a new paradigm of fungal exposure.

 

Direct evidence of the associations between fungal fragments and building-related disease is lacking and in order to gain a better understanding, it will be necessary to develop diagnostic reagents and detection methods, particularly for sub-micronic particles. Monoclonal antibody-based assays enable the measurement of individual antigens but interpretation can be confounded by cross-reactivity between fungal species. The recent development of species-specific monoclonal antibodies, used in combination with a fluorescent-confocal HIA technique should, for the first time, enable the speciation of morphologically indiscernible fungal fragments. The application of this method will help to characterize the contribution of fungal fragments to adverse health effects due to fungi.

 

Fungi Are a Diverse Kingdom
  • 80,000 species known
  • More than 112 fungal genera identified as allergenic
  • Relationship between fungal exposure and clinical outcomes remains unclear
  • Measurement of exposure to fungal allergens has been restricted to the spores of a select number of fungi
  • The potential of different fungi or fragments to cause or aggravate adverse health effects remains unclear
  • No consensus on thresholds for specific risks.

Conclusion

  • Numbers of fungal fragments are in most cases more common than airborne spores.
  • Larger fungal fragments are a significant aeroallergen source, presenting a new paradigm of natural fungal exposure.
  • Currently, the airborne distribution and immunoreactivity of smaller submicron fungal fragments remains unknown.
  • The development of innovative immunodetection methods will help to elucidate adverse health effects due to smaller fungal fragments in the environment.

Source: Airborne Fungal Fragments and Allergenicity; Brett J. Green, PhD;
National Institute for Occupational Safety and Health; Centers for Disease Control and Prevention; Morgantown, WV.



Facts about Fungal Fragments:  Created on December 30th, 2007.  Last Modified on December 30th, 2007
Disclaimer ↓

The Cleaning Industry Research Institute (CIRI) is a 501.c.3 not-for-profit scientific, educational and research organization that applies science to the practice and improvement of cleaning and maintenance.

 

This abstract/brief is presented under the recognized "fair use" doctrine with respect to article copyright and intellectual property. Readers are encouraged to secure the full article from the originating publication source. Articles also may be obtained through a librarian, an information specialist or inter-library loan. In cases where payment is required under copyright it can be processed through a reference library or the Copyright Clearance Center at www.copyright.com.

 

CIRI provides no warranty, expressed or implied, and assumes no legal liability for the accuracy, completeness or usefulness of any information disclosed on its site. The views and opinions of authors expressed herein do not necessarily reflect those of CIRI principals, executives, science advisors or affiliates.

 

Comments

Comments

Members

Member Access

Sorry, only CIRI Members are allowed to comment.

 

If you're a member, sign in:

Not a CIRI Member? Join Today to tap CIRI knowledge and networking resources

Sorry, there are currently no comments on this article...

About CDC

The Centers for Disease Control and Prevention (CDC) is one of the 13 major operating components of the Department of Health and Human Services (HHS), which is the principal agency in the United States government for protecting the health and safety of all Americans and for providing essential human services, especially for those people who are least able to help themselves.

Since it was founded in 1946 to help control malaria, CDC has remained at the forefront of public health efforts to prevent and control infectious and chronic diseases, injuries, workplace hazards, disabilities and environmental health threats.
 
 

 

 

 

Popular Topics: Swine Flu | H1N1 | MRSA | Staph | Norovirus | Flu | E. Coli | C. Difficile | Salmonella | Green Cleaning | Cleaning for Health | Nosocomial Infections | Disinfection | Bacteria | Viruses | Indoor Air Quality | Asthma | Allergies | Allergen | Mold

 

© 2007-2010 The Cleaning Industry Research Institute
A 501.c.3 not-for-profit scientific, educational and research institute
1988 Central Avenue
Albany, NY 12205

Phone: (888)285-2474
Fax: (518)456-6445
Privacy Policy | Shipping Policy | Return Policy & Procedure